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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPDL3B
All Species:
23.64
Human Site:
S374
Identified Species:
47.27
UniProt:
Q92485
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92485
NP_001009568.1
455
50814
S374
V
P
D
A
S
A
H
S
M
H
T
V
L
D
R
Chimpanzee
Pan troglodytes
XP_001151336
455
50854
S374
V
P
D
A
S
A
H
S
M
H
T
V
L
D
R
Rhesus Macaque
Macaca mulatta
XP_001108274
453
51294
T375
W
K
L
E
Y
T
L
T
Q
T
Y
D
I
E
D
Dog
Lupus familis
XP_544464
468
52011
S386
V
P
D
A
G
A
R
S
M
H
A
A
L
G
R
Cat
Felis silvestris
Mouse
Mus musculus
P58242
456
51581
S374
V
P
D
A
S
V
S
S
M
H
T
A
L
T
R
Rat
Rattus norvegicus
Q641Z7
445
49877
L367
K
G
E
S
N
W
T
L
E
Y
T
L
T
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516772
436
49539
S352
V
K
D
L
H
P
Q
S
L
H
G
L
A
K
Q
Chicken
Gallus gallus
XP_001232192
454
51318
S369
V
P
D
G
S
T
H
S
M
Q
T
V
L
E
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692822
457
52265
S375
V
P
D
A
S
P
A
S
M
H
R
V
M
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_729555
488
55653
H383
E
I
S
A
V
A
L
H
N
F
A
E
R
F
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_505620
755
86279
T376
T
G
D
I
N
P
T
T
M
S
A
L
L
D
K
Sea Urchin
Strong. purpuratus
XP_786766
452
51341
F374
L
D
Q
L
V
D
K
F
S
S
E
E
S
S
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
40.2
76.2
N.A.
75.6
39.3
N.A.
38
61
N.A.
54.2
N.A.
28.6
N.A.
23.8
39.3
Protein Similarity:
100
99.5
58
83.9
N.A.
86.1
58.4
N.A.
55.8
74
N.A.
71.1
N.A.
47.9
N.A.
37
58
P-Site Identity:
100
100
0
66.6
N.A.
73.3
6.6
N.A.
26.6
73.3
N.A.
66.6
N.A.
13.3
N.A.
26.6
0
P-Site Similarity:
100
100
20
66.6
N.A.
73.3
40
N.A.
46.6
80
N.A.
80
N.A.
13.3
N.A.
53.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
50
0
34
9
0
0
0
25
17
9
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
67
0
0
9
0
0
0
0
0
9
0
25
9
% D
% Glu:
9
0
9
9
0
0
0
0
9
0
9
17
0
25
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
9
0
0
0
9
0
% F
% Gly:
0
17
0
9
9
0
0
0
0
0
9
0
0
9
0
% G
% His:
0
0
0
0
9
0
25
9
0
50
0
0
0
0
0
% H
% Ile:
0
9
0
9
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
9
17
0
0
0
0
9
0
0
0
0
0
0
9
9
% K
% Leu:
9
0
9
17
0
0
17
9
9
0
0
25
50
0
0
% L
% Met:
0
0
0
0
0
0
0
0
59
0
0
0
9
0
0
% M
% Asn:
0
0
0
0
17
0
0
0
9
0
0
0
0
0
0
% N
% Pro:
0
50
0
0
0
25
0
0
0
0
0
0
0
0
9
% P
% Gln:
0
0
9
0
0
0
9
0
9
9
0
0
0
9
9
% Q
% Arg:
0
0
0
0
0
0
9
0
0
0
9
0
9
0
50
% R
% Ser:
0
0
9
9
42
0
9
59
9
17
0
0
9
9
0
% S
% Thr:
9
0
0
0
0
17
17
17
0
9
42
0
9
9
9
% T
% Val:
59
0
0
0
17
9
0
0
0
0
0
34
0
0
0
% V
% Trp:
9
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
0
0
9
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _